| Polytrim (U.S.N.L.M.) | |
|---|---|
| Dosing/ Conjunctivitis | 1 drop q 3hr for 7 to 10 days. |
| Chem Specs | polymyxin B sulfate 10,000 units/mL; trimethoprim sulfate equiv 1 mg/mL. |
| Quantities | 10ml |
| Cost | 17.99 generic |
| Class | Polypeptide / Sulfonamide |
| Action | Trimethoprim - prevents bacterial folic acid synthesis (inhibits bacterial DNA synthesis). Polymyxin B - surfactant acts on phospholipids of bacterial cell membrane. |
| Activity |
Active against a wide variety of aerobic gram-positive and gram-negative ophthalmic pathogens including Staph aureus and Pseudomonas aeruginosa. Fewer than 10% of S. aureus and methicillin-resistant S. aureus resistant to trimethoprim (2018). Active against a wide variety of aerobic gram-positive and gram-negative ophthalmic pathogens including Staph aureus and Pseudomonas aeruginosa. Fewer than 10% of S. aureus and methicillin-resistant S. aureus resistant to trimethoprim (2018). |
| Usage | Indicated for surface ocular bacterial infections, including acute conjunctivitis, and blepharoconjunctivitis. Indicated for surface ocular bacterial infections, including acute conjunctivitis, and blepharoconjunctivitis. |
| Excellent coverage of Haemophilus influenzae and Streptococcus pneumoniae makes Polytrim popular in pediatric usage. Excellent coverage of Haemophilus influenzae and Streptococcus pneumoniae makes Polytrim popular in pediatric usage. |
|
| Contraindications | Known hypersensitivity to components. |
| Pediatric use | > 2 months |
| Pregnancy | No large well-controlled studies on the use of trimethoprim in pregnant women. Small retrospective studies have not shown teratogenicity. |
| Useful as adjunctive therapy when fluoroquinolone resistance is suspected. |