| Tobrex Ointment (U.S.N.L.M.) | |
|---|---|
| Dosing/ | bid, tid, (or q3-4 hr for severe disease) then bid or tid till end. |
| Chem Specs | tobramycin 0.3% |
| Quantities | 3.5 gm tube |
| Cost | 262.00 |
| Class | Aminoglycoside |
| Action | Prevents bacterial protein synthesis (binds to ribosome s30 or s50) |
| Activity | Active against a wide variety of gram-negative and gram-positive bacteria includings some penicillin-resistant and gentamicin-resistant strains . |
| Usage | Indicated in the treatment of external infections of the eye and adnexa. |
| Increasing resistance from community-acquired infections. Aminoglycoside toxicity possible with pre-sensitized pts. or with extended use. Polysporin is the usual alternative. |
|
| Contraindications | Known hypersensitivity to any of its components. |
| Pediatric use | > 2 months |
| Pregnancy | 3 animal studies have failed to demonstrate fetal risk. No adequate and well-controlled studies in pregnant women. |